ICGC-TCGA Mutation Calling Challenge Webinar

The ICGC-TCGA DREAM Genomic Mutation Calling Challenge (open for participation Nov 2013 — Summer 2014) is an international effort to improve standard methods for identifying cancer-associated mutations and rearrangements in whole-genome sequencing (WGS) data. The goal of this somatic mutation calling (SMC) Challenge is to identify the most accurate mutation detection algorithms, and establish the state-of-the-art. The algorithms in this Challenge must use as input WGS data from tumour and normal samples and output mutation calls associated with cancer.

In this January 29, 2014 webinar, Challenge participants were invited to hear presenations and participate in a live Q&A session about the Challenge. The webinar video consists of the following three sections:

  1. Background and motivation for the Challenge (Paul Boutros: SMC Challenge Leader)
  2. Demo of Challenge web services to show you how to participate (Chris Bare: Sage Bionetworks)
  3. Answering your questions in real-time



For more information about all DREAM Challenges, please visit the DREAM web presence on Synapse.


About Brian Bot
I am a Principal Scientist working in Computational Oncology at Sage Bionetworks in Seattle, Washington and Community Manager for our technology platforms. Previously, I worked in the Department of Biomedical Statistics and Informatics at the Mayo Clinic for 7 years. This work included 7 years of dealing with cancer clinical trial data as part of the Mayo Clinic Cancer Center (MCCC). I have extensive experience in working with clinical and genomic data and have a passion for exploring innovative ways to make science more open and transparent. My current work involves both doing innovative research in computational oncology as well as serving as a bridge between biomedical researchers and technology development. At its heart, this work is driven to re-envision how scientists can ensure reproducibility of their research results and communicate complex science to one another and to the public at large. I have been an invited speaker at a number of national and international events to share my experiences living at the intersection of biomedical research and technology.

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